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KMID : 0604520080340010015
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Journal of the Society of Cosmetic Scientists of Korea
2008 Volume.34 No. 1 p.15 ~ p.23
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Study on Encapsulation Efficiency and Preparation of SLN Using Conjugated New Whitening Agent(LA-PEG) and Its Cosmetic Application
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Kang Ki-Choon
Pyo Hyeong-Bae
Lee Cheong-Hee
Kim Tae-Hoon
Ma Sang-Chol
Im Won-Cheol
Jeong Noh-Hee
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Abstract
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This study is on encapsulation of a new whitening agent, LA-PEG using solid lipid nanoparticle(SLN) method, one of nanoparticle preparation method. Classical method has high capsulation efficiency for hydrophobic compounds but has demerit of low capsulation efficiency() for hydrophilic compounds. Purpose of this study is preparation of SLN that has higher skin penetration effect compared with general liposome, and also has higher encapsulation efficiency of hydrophilic compounds. For SLN preparation, coconut oil, macadamia oil, and jojoba oil were used. As a result, SLN preparation using coconut oil(include LA-PEG) has the most high encapsulation efficiency and also has the smallest average particle size(270 nm). SLN prepared with macadamia oil and 1% of Tween 60 has the largest particle size. Base made with coconut oil and 2% of Tween 60 showed the fastest release and base made with macadamia oil and 2% of Tween 20 showed the latest release.
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KEYWORD
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solid lipid nano-particle, hydrophilic drugs, hydrophobic drugs, encapsulation efficiency, LA-PEG
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